And the sixth angel poured out his bowl upon the great river, the Euphrates…Revelation 16:12.
The great river Euphrates is prominent throughout the Bible, beginning in the book of Genesis with creation. This prominence continues in prophecy, right into the last chapters of the book of Revelation. When it comes to prophecy, there is indeed a Euphrates connection!
Babylon is being rebuilt on its original site by Iraq. The prophets Isaiah (Is 13) and Jeremiah (Je 50-51) , and the apostle John (Re 18) each declared that Babylon would rise again, reemerging even beyond its former glory. It will be a great city, the hub of planetary commerce and religion, the capital of the world, and the center of the Antichrist. We would therefore expect it to be a prime habitat of Satan-and indeed it is! The Bible specifically designates it at the end time as “a dwelling place of demons and a prison of every unclean spirit” (Re 18.2). This demon infested metropolis will be located on its original site of old—the Euphrates River!
Near the end of the Great Tribulation, at the sounding of the 6th Trumpet Plague, 200 million demonic spirits are released to kill 1/3 of mankind (Re 9.13-21). We know they are demon angels because their leaders are four fallen angels. The description further confirms they are creatures from the demonic dimension (see The Assyrian Connection, by Phillip Goodman, p. 189; Prescott Press, 1993). From where does the assault of this demonic hoard originate? …”The great river Euphrates!” (Re 9.14)
When the Antichrist and his False Prophet deceive all the nations into converging on Israel to blot out the Jews, the call to arms is actually spread across the planet with the assistance of demonic messengers (Re 16.12-16). They seduce the nations through a generous dose of lying signs and wonders gathering them to the Holy Land. The focus of this satanic activity?…”The great [but providentially dried] river, the Euphrates.”
The Euphrates river is located in the land of the ancient sister empires, Assyria and Babylon. It is from here that the Bible projects the rise of the Antichrist at the end of history. Through a compelling array of evidence, we see the land of what is modern day Syria/Iraq as that part of the neo-Roman empire which gives birth to the Antichrist (see The Assyrian Connection, cited above). The ‘Euphrates Connection’ so prominent in the Bible lends great weight to this evidence.
The staying power of the Euphrates Connection will, in fact, persist right up to a certain ‘hour and day and month and year” of the end time (Re 9.15). But then there is another “day and hour no one knows”—a day when the Lord will come “in His glory, and all the angels with Him, [to] sit on His glorious throne.” (Ma 24.42; 25.31) That will be the end of the “Euphrates Connection!”